Understanding Hypertrophic Cardiomyopathy (HCM)

HCM is the most common inherited cardiovascular disorder, affecting approximately 1 in 500 individuals worldwide. However, only about 1 in 3,200 people in the United States are diagnosed with HCM and experience symptoms.1

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current therapies

Treatment options vary depending on the symptoms but can include beta blockers and surgery. These therapies indirectly improve symptoms of HCM. Despite current pharmacotherapies, invasive surgery may be required to reduce thickened myocardium.

References:

  1. Maron MS, Hellawell JL, Lucove JC, Farzaneh-Far R, Olivotto I. Occurrence of Clinically Diagnosed Hypertrophic Cardiomyopathy in the United States. Am J Cardiol. 2016;117(10):1651-1654.
  2. Hypertrophic Cardiomyopathy: Causes. Symptoms & Treatments. Cleveland Clinic. Accessed August 13, 2020. https://my.clevelandclinic.org/health/diseases/17116-hypertrophic-cardiomyopathy
  3. Konno T, Chang S, Seidman JG, Seidman CE. Genetics of Hypertrophic Cardiomyopathy. Curr Opin Cardiol. 2010;25(3).
  4. Spudich JA. Three perspectives on the molecular basis of hypercontractility caused by hypertrophic cardiomyopathy mutations. Pflugers Arch. 2019;471(5):701-717.
  5. Gersh BJ, Maron BJ, Bonow RO, Dearani JA, Fifer MA, Link MS, …Yancy CW. Guideline for the Diagnosis and Treatment of Hypertrophic Cardiomyopathy. American College of Cardiology Foundation and the American Heart Association. 2011;2768.
  6. Suboc, T. Hypertrophic Cardiomyopathy. Merck Manuals Professional Edition. Updated October 2019. Accessed August 19, 2020. https://www.merckmanuals.com/professional/cardiovascular-disorders/cardiomyopathies/hypertrophic-cardiomyopathy
  7. Hypertrophic cardiomyopathy (HCM). Cardiomyopathy UK. Updated June 2017. Accessed August 13, 2020. https://www.cardiomyopathy.org/hypertrophic-cardiomyopathy/intro
  8. Hypertrophic Cardiomyopathy (HCM). American Heart Association. Updated April 17, 2020. Accessed August 19, 2020. https://www.heart.org/en/health-topics/cardiomyopathy/what-is-cardiomyopathy-in-adults/hypertrophic-cardiomyopathy
  9. Liew AC, Vassiliou VS, Cooper R, Raphael CE. Hypertrophic Cardiomyopathy—Past, Present and Future. J Clin Med. 2017;6(12).
  10. ck-274. Accessed August 19, 2020. https://cytokinetics.com/ck-274/

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